In the present study, we investigated the cellular and molecular mechanisms involved in NSCLC fate regulation, particularly in (1) the role and regulation of EGFR; (2) how the crosstalk between Akt and p53 regulates EGFR and ROS production, and (3) whether ROS is associated with CDDP-induced apoptosis. This evidence concerns the gene TP53 and non-small cell lung carcinoma.