To investigate whether p53 is involved in the regulation of EGFR in NSCLC cells, chemoresistant H1299 (p53 null) cells were infected with adenoviral construct (Adv)-wild-type p53 (Adv-p53) or Adv-GFP (as control) at different multiplicity of infection (MOI: 0–1.0; 5 h), and then treated with CDDP (10 μM, 24 h). This evidence concerns the gene TP53 and infection.