To determine if NSCLC cells with different EGFR and p53 mutational status exhibit different CDDP sensitivity, we cultured multiple NSCLC cells (A549, H1299, H1650 and H1975) with CDDP (10 μM; 24 h) and assessed the protein level of cleaved PARP and the apoptosis rate (%) by Western blot (WB) and Hoechst staining, respectively. The gene discussed is TP53; the disease is non-small cell lung carcinoma.