EGFR and non-small cell lung carcinoma: To further demonstrate that Akt regulates EGFR content and participates in a positive feedback loop on EGFR signaling, chemosensitive A549 NSCLC cells were infected with a constitutively activated Akt (Adv-AAkt) or a control (Adv-GFP) and then treated with CDDP (10 μM, 24 h).