CHEK2 and posterior cortical atrophy: Epidemiological studies suggest that PCa is hormone-dependent and is associated with inflammation, as suggested by the detection of PCa susceptibility genes involved, such as RNAseL, MSR1, TLR4, MIC1, PON1, BRCA2, CHEK2, and OGG, which have a role in prostate carcinogenesis, and also in the host response to infection, inflammation, and oxidative stress [24, 25].