TGM2 and Familial prostate cancer: On the other hand, the differentiation treatment with γ-tocopherol of prostate carcinoma PC3 cells induced a decrease in the progression into the S-phase, which was associated with TG2 upregulation and increased activity, significant decrease of DNA synthesis, and protein expression of cyclins D1 and E. TG2 upregulation and activation could be part of a larger pathway that promotes the attenuation of prostate cancer malignancy [98].