Compared to WT CRC mice (Figure 3(e)), MIF−/− CRC mice (Figures 3(f) and 3(h)) showed larger tumors with less-differentiated glands containing more stratified epithelium that showed larger nuclei and more numerous mitotic figures that were frequently atypical; in the base of these tumors (Figure 3(g)), there were nodules of polygonal undifferentiated cells that were invading blood and lymphatic vessels, denoting higher malignancy levels in contrast with the tumors observed in WT CRC (Figure 3(h)), which did not exhibit these histological abnormalities. The gene discussed is MIF; the disease is colorectal carcinoma.