A previous study, where the colon 26 cancer cell line was inoculated in the mice, showed that the treatment with anti-MIF antibody reduced the tumor size and the angiogenesis in it [13], whilst the transplantation of the CT-26 colon carcinoma cell lines and subsequent administration of anti-MIF antibodies or the synthetic MIF inhibitor ISO-1 resulted in the reduction of tumor volume [29]. This evidence concerns the gene MIF and neoplasm.