TTR and AL amyloidosis: Early diagnosis is crucial for several reasons: a) overall survival is poor once cardiac involvement is present [7, 8]; b) chemotherapy followed by stem cell transplantation has improved prognosis for AL amyloidosis significantly [5, 8]; c) antibody-mediated fibril phagocytosis as well as TTR gene silencers and protein stabilisers are emerging including recent positive outcome trials on all-cause mortality and hospitalisation [9, 10].