Mutations in TP53 are frequently found in human cancers and often result in amino acid substitutions.45 In biliary tract cancers, the role of p53 is still unclear, the mutation rate ranges from 33 to 65% depending on the anatomical site in the biliary tract.29 Mutations in the whole coding sequence (11 exons) were screened. Here, TP53 is linked to biliary tract neoplasm.