The IHC analysis using TMAs of GBM tissue specimens, for YBX1 and its interacting proteins (EGFR, MAPK1, CD44, TNC, MMP13 and SOX2) with documented role in cell invasion revealed distinct concordance between their expression, supporting a regulatory link between YBX1 and these proteins (Fig. 7). The gene discussed is MAPK1; the disease is glioblastoma.