Out of eight transcription factors used, the transcription factor YBX1 was found to be interacting with the key hub molecules like epidermal growth factor receptor isoform b (EGFR), mitogen-activated protein kinase 1 (MAPK1), integrin beta chain, beta 3 (ITGB3), and these in turn interacting further with several other molecules involved in tumor cell invasion. This evidence concerns the gene MAPK1 and neoplasm.