With this hypothesis, we verified the expression of YBX1 and six of the interacting proteins (EGFR, MAPK1, CD44, tenascin C (TNC), matrix metalloproteinase 13 (MMP13) and SOX2) involved in cell invasion network by IHC on Tissue microarrays using clinical specimens of GBM. The gene discussed is SOX2; the disease is glioblastoma.