Activated EGFR and MAPK1 are involved in the Epithelial to mesenchymal transition by promoting transcription factors such as zinc finger protein SNAI1, and Twist-related protein 1 (TWIST1) in GBM, which in turn induce expression of cell invasion associated genes/proteins such as MMPs, Secreted protein acidic and rich in cysteine (SPARC)25. The gene discussed is SPARC; the disease is glioblastoma.