On the other hand miRNAs miR-101, miR-124, miR-137, miR-218, miR-148b and miR-1 that are down regulated in GBM are known to target some of the GBM-overexpressed transcription factors such as Nuclease-sensitive element-binding protein 1 (YBX1 or YB1), activated RNA polymerase II transcriptional coactivator p15 (SUB1) and NF1B and other transcriptional regulators like HMGB1/2, PTBP1, PARP1, SMARCA5, LMNB1, protein BUD31 homolog (BUD31) present in the network. This evidence concerns the gene PARP1 and glioblastoma.