The significantly increased risk of breast cancer according to the increasing number of RORA rs1482057 A allele was found in women who carry the GG genotype of NPAS2 rs3820787 or the AA genotype of CUL1 rs758880 (Table 3), otherwise with different genotypes, increment of RORA rs1482057 A genotype showed no association or decreased tendency for development of breast cancer. Here, CUL1 is linked to breast cancer.