Studies on human glioma cell lines demonstrated that a mutation T14634C in mtDNA encoded Complex I ND6 subunit (NADH dehydrogenase) causing amino acid change M14V significantly disrupt the orientation of entire ND6 protein within mitochondrial membrane and would alter the interaction of the individual helices of each protein thus associated with hypoxia sensitive phenotype41. The gene discussed is ENSG00000251605; the disease is central nervous system cancer.