The classical/canonical MAPK signaling begins with receptor tyrosine kinase activation on the cell membrane and propagates through Ras-Raf-Mek-Erk for various biological processes such as cell proliferation, cell cycle regulation, cell survival and apoptosis, etc. In a cancer context, the MAPK pathway has a well-documented role in contributing to disease progression and metastasis. This evidence concerns the gene NTRK1 and cancer.