As for the tumors of the CESC cohort, interferon alpha (IFNα) and gamma (IFNγ) responses and apoptosis of cancer cells were significantly elevated while the oncogenesis related pathways of glycolysis, MYC signaling, TGF-β signaling, angiogenesis, EMT, hypoxia and mitotic process were significantly inhibited in the patients of the high Immu6Metagene signature expression compared to the low expression (Fig. 6B). This evidence concerns the gene TGFB1 and cancer.