In CESC, the higher 6-gene signature expression in the low risk group was driven by the higher expressions of another set of 5 genes, i.e., CD27, CEACAM1, CTLA4, PDCD1LG2, and TNFRSF18 (Fig. S8C,D). The gene discussed is TNFRSF18; the disease is cervical squamous cell carcinoma.