The analysis of RNAi data found that six genes - CD27, CEACAM1, CTLA4, LRIG1, PDCD1LG2 (PD-L2), and TNFRSF18 had the dependency scores ranking within the highest 1% of the 17,080 genes targeted by pooled RNAi screening in 43 cancer cell lines (Figs 2 and 3), suggesting the enrichment of the cancer cells deprived of the corresponding gene expression and thus supporting their role as tumor suppressor. The gene discussed is TNFRSF18; the disease is cancer.