The analysis of RNAi data found that six genes - CD27, CEACAM1, CTLA4, LRIG1, PDCD1LG2 (PD-L2), and TNFRSF18 had the dependency scores ranking within the highest 1% of the 17,080 genes targeted by pooled RNAi screening in 43 cancer cell lines (Figs 2 and 3), suggesting the enrichment of the cancer cells deprived of the corresponding gene expression and thus supporting their role as tumor suppressor. This evidence concerns the gene PDCD1LG2 and neoplasm.