Though HPV is the most common factor of cervical cancer, yet alone it is not sufficient to develop cervical cancer and requires several chromosomal changes and genetic damages/alterations, including viral DNA integration itself and mutations mainly in TP53 and Rb20–22, along with other risk factors such as smoking, multiple sexual partners, early sexual debut and low socioeconomic status23. This evidence concerns the gene TP53 and cervical carcinoma.