Moreover, ormeloxifene works excellent in combinational therapies as well with curcumin or resveratrol64 and with glycine soya65 against breast cancer; results from these studies suggest that ormeloxifene works via both ER dependent and ER independent mechanisms and also it seems to work through various other pathways such as PI3K-Akt, STAT3 and SHH40–42 which are responsible for proliferation and cell cycle progression. Here, ESR1 is linked to breast cancer.