Therefore, this can be interpreted that ormeloxifene driven inactivation of PI3K-Akt signaling in this study is HPV E6/E7 mediated but future experiments are warranted to determine the underline molecular mechanism for ORM’s action in cervical cancer as ormeloxifene has been reported to work through both HPV dependent and independent mechanisms. This evidence concerns the gene AKT1 and cervical carcinoma.