Importantly, correlation analysis further displayed significant positive associations between oxLDL and Nogo-B, oxLDL and CD36, CD36 and Nogo-B, as well as between CEBPβ and Nogo-B at protein level (Fig. 7c), demonstrating a strong activation of the oxLDL-CD36-CEBPβ cascade for Nogo-B induction in clinical NAFLD-associated HCC. This evidence concerns the gene RTN4 and hepatocellular carcinoma.