RTN4 and hepatocellular carcinoma: Ectopic expression of Nogo-B in two cell lines with low Nogo-B expression, the immortalized hepatocyte LO2 and HCC cell line SMMC-7721 (Fig. 1e and Supplementary Fig. 1H), promoted cell growth (Fig. 1f and Supplementary Fig. 1I), while lentiviral-mediated knockdown of Nogo-B in SK-Hep1 and MHCC97H cells resulted in remarkable growth inhibition (Fig. 1g and Supplementary Fig. 1J).