Considering Mfn1/2iΔAEC2 mice develop spontaneous lung fibrosis, we evaluated whether the transcriptomic response in Mfn1/2−/− AEC2 cells at baseline resembled those in the Mfn1−/− or Mfn2−/− AEC2 cells after bleomycin treatment, and whether Mfn1/2−/− AEC2 cells had functional annotations in common with control AEC2 cells after bleomycin treatment. This evidence concerns the gene MFN2 and pulmonary fibrosis.