In Rag1–/– mice, α-DR3 treatment similarly caused a more rapid rate of weight loss (Fig. 7i), shorter colons (Fig. 7j; Supplementary Fig. 8G), increased number of neutrophils and eosinophils in lamina propria (Fig. 7k), as well as more severe intestinal pathology during DSS-induced colitis compared with controls (Fig. 7l; Supplementary Fig. 8H). The gene discussed is RAG1; the disease is colitis.