CD4 and glomerulonephritis: Compared to mice immunized with cured heat-killed S. aureus JH1, mice immunized with S. aureus JH1 containing pSJH101 developed glomerulonephritis with pathological albuminuria, glomerular focal, and segmental necrosis and infiltrates of CD4+ T cells, CD8+ T cells and macrophages (Fig. 8).