We applied this functional approach and observed that leukemia cells with strong functional dependence on BCL-2 (BAD-HRK priming) showed high VEN sensitivity upon ex vivo exposure (low EC50 values), in line with previous reports on BCL-2 dependence and VEN sensitivity measured in isolated BCP-ALL and T-ALL cells17–19,34. The gene discussed is HRK; the disease is leukemia.