Importantly, this finding of a highly indicative value of functional BCL-2 dependence for in vivo VEN sensitivity was confirmed in an independent set of preclinically treated primograft samples and extended to T-ALL and TCF3/HLF rearranged ALL, a rare subgroup associated with early relapse and dismal outcome35, for which in vitro and preclinical in vivo response to VEN had recently been reported32. This evidence concerns the gene HLF and acute lymphoblastic leukemia.