Moreover, we have previously reported that tumours from disc large 1 Drosophila mutant larvae (dlg40.2 hereafter referred to as dlg), activate Toll pathway in the Drosophila fat body in an Egr-dependent manner, and this immune activation is necessary for TNF-dependent tumour cell death (Parisi et al., 2014). The gene discussed is TLR4; the disease is neoplasm.