For example, during the progression of neuroblastoma development, Lgr5 enhanced tumor survival and proliferation through the regulation of phosphorylation of mitogen/extracellular signal-regulated kinases (MEK1/2) and extracellular signal-regulated kinases (ERK1/2), besides through reinforcement of Wnt/β-catenin signaling [108]. Here, LGR5 is linked to neoplasm.