We showed that levels of Δtau314 proteins are 1.6- to 5.6-fold higher in both regions in HD patients compared to non-HD individuals, that levels of Casp2 are 1.7- to 2.5-fold higher in HD patients than in non-HD individuals, and that levels of Casp2 and Δtau314 proteins are correlated in both studied brain structures. The gene discussed is CASP2; the disease is Huntington disease.