Whereas ATM germline mutations or deficiencies causes predisposition for malignancies [43, 44], neurological disorders [45], growth retardation, genetic instability in solid tissues [46], and accelerated aging after genotoxic stress [47], DNA-PK deficiencies are more limited in their phenotypic expression to the immune-system and gametogenesis [48]. This evidence concerns the gene PRKDC and nervous system disorder.