There was a statistically significant covariation between VDR negativity and many tumor characteristics associated with poor prognosis: large tumor size (p = 0.002), high Nottingham grade (p < 0.001), negative ER status (p < 0.001), negative PgR status (p < 0.001), and high Ki67 expression (p < 0.001). The gene discussed is PGR; the disease is neoplasm.