Those infected by the influenza A/H1N1 who did not receive antiviral therapy in 48 h from onset were more frequently experiencing cough (94.1% vs. 67.6%, p < 0.01), leukopenia (25.5% vs. 17.6%, p < 0.05) and increasing in CRP (85.7% vs. 67.9%, p < 0.05), LDH (54.4% vs. 24.0%, p < 0.01) and ESR (71.2% vs. 33.3%, p < 0.01) (Additional file 5: Table S2). The gene discussed is ESR1; the disease is Decreased total leukocyte count.