Strikingly, like ZNF471 and ZNF671, 27 of the top 200 hypermethylated genes identified in this study map to zinc-finger genes, with 75% mapping to the Chr19q41–43 cluster, suggesting that altered expression of these DNA-binding proteins maybe involved in the development of gestational choriocarcinoma. This evidence concerns the gene ZNF471 and gestational choriocarcinoma.