Of the promoters gaining methylation in our sample, many have already been shown to have tumour suppressor activity, including RORa, FAN1, PRDM1, CYGB, L3MBTL4, EPB41L3, with ZNF471 and ZNF671 being specifically silenced by methylation [29, 30]. This evidence concerns the gene EPB41L3 and neoplasm.