ESR1 and breast carcinoma: The staining results showed that both cytoplasmic and nuclear FOXO3 was positively correlated with the expression levels of SIRT6, (*** p < 0.001) and SIRT1 (*** p < 0.001) in ER+HER2− breast cancer patients and cytoplasmic FOXO3 with SIRT6 (* p < 0.05) in triple-negative breast cancer (TNBC) samples (Figure 8B).