Several molecules PI3K-p110 α,γ,δ sub unit inhibitor were under trial phase 1–2 for NHL, like as AMG319 [34], Buparlisib [35,36], Copanlisib [37], CUDC-907 with additional inhibition of HDAC [38], Dactolisib with additional inhibition on mTOR-p70S6K [39], Duvelisib [40], Getadolisib is a pan-PI3K, mTOR inhibitor. This evidence concerns the gene MTOR and non-Hodgkin lymphoma.