Enhanced blood vessel density in psoriatic S1pr1∆MΦ mice could be explained by the enhanced expression of Vegfa along with its receptors Flt1 and Kdr. Conversely, downregulation of Vegfc, a lymphangiogenic factor, despite its receptor (Kdr; angiogenic and Flt4; lymphangiogenic) being expressed, might explain the reduced neolymphatic vessels formation in these mice during skin inflammation. The gene discussed is VEGFA; the disease is dermatitis.