SMC2 and ovarian carcinoma: They identified an index variant (rs200182588) at the SMC2 locus (9q31) that localizes to the 5′-untranslated region of SMC2. On the basis of our clinical and mechanistic findings, it is tempting to speculate that this alteration may adversely impact mRNA stability and/or expression resulting in reduced condensin function that induces CIN and contributes to breast and ovarian cancer pathogenesis.