In one study, we found SNP rs1558902 in obesity gene FTO significantly interacted with dietary protein intake on two-year changes in fat-free mass (FFM, p-interaction = 0.034) and total percentage of fat mass (FM%, p-interaction = 0.049), as well as SAT (p-interaction = 0.001), VAT (p-interaction = 0.012), and total adipose tissue (TAT, p-interaction = 0.002) [81]. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.