TARDBP and neuroblastoma: When TDP-43 inclusions were internalized into murine N2A neuroblastoma cells using lipofectamine, a dense nuclear localization and a diffuse cytosolic distribution of TDP-43 (green channel) were shown by scanning confocal microscopy using monoclonal antibodies that recognize both murine and human isoforms of TDP-43 protein (Figure 1A,B).