Fibulin-1 (FBLN1) was described as being up-regulated in high-grade astrocytoma, and Fibulin-2 (FBLN2) and Fibulin-5 (FBLN5) was described as being down-regulated in grade II/III/IV compared with grade I astrocytoma [37]. The gene discussed is FBLN5; the disease is astrocytoma (excluding glioblastoma).