Shen et al. identified 19 differentially regulated proteins in a systematic review conducted on CSF related glioma biomarkers, then, in an independent cohort, further validated 4 candidate proteins (Interleukin-6 (IL-6), Galanin peptides (GALA), Endoplasmic reticulum chaperone BiP (BIP), and Protein Wnt-4 (WNT4)) that could be studied to better understand how glioma cells interact and which pathways are activated in the local microenvironment of this tumor [44]. The gene discussed is HSPA5; the disease is central nervous system cancer.