Tumors that did not harbor these mutations were found to have mutations in CYSLTR2, a G-protein-coupled receptor, in 4% of samples and in PLCB4, a downstream effector of GNAQ signaling in 2.5% of samples [17,19,23], highlighting the involvement of G-protein signaling in the biology of uveal melanoma. This evidence concerns the gene CYSLTR2 and uveal melanoma.