In p53+/−;p63+/− or p53+/−;p73+/− double heterozygous mice develop a higher frequency of metastatic tumors than p63+/−;p73+/− mice [5] (the relevant mouse models are summarized at: http://p53.free.fr/p53_info/Mouse_model/p53_mouse_models.html). This evidence concerns the gene TP53 and metastatic neoplasm.