TGFB1 and neoplasm: In this context, general immunological tolerance mechanisms play an important role, for example, regulatory cells of the immune system, such as regulatory T cells (Treg) and microglia but also soluble factors such as interleukin-10 (IL-10) and transforming growth factor beta (TGF-β), induce an immunosuppressive environment and promote tumor progression, infiltrative growth/migration, and tumor recurrence [13,14].