THBD and endothelial dysfunction: Moreover, positive correlations between viral load and endothelial dysfunction markers (Angiopoietin-2 (r = 0.45 p = 0.0001), PAI-1 (r = 0.43 p = 0.0002), ADAMTS3 (r = 0.27 p = 0.0266), d-dimer (r = 0.31 p = 0.01), sPECAM-1 (r = 0.41 p = 0.0007), TF (r = 0.34 p = 0.0047) and TM (r = 0.43 p = 0.0002)) were found in CCHF patients.