What is more, patients with HFRS had higher markers of endothelial dysfunction (Angiopoetin-2, sVCAM-1, PAI-1, ADAMTS13, d-dimer, sP-Selectin, fibrinogen, vWF, sE-Selectin, sPECAM-1, TF and TM) than CCHF patients. This evidence concerns the gene SERPINE1 and endothelial dysfunction.