STX5 and Parkinson disease: Stx5 may also play a role in Parkinson’s disease, as a disease-related mutant of α-synuclein (A53T) binds to Stx5 and GosR2, and this reduces the formation of the Stx5-GosR2-Bet1-Sec22b SNARE complex, thereby possibly impairing ER-Golgi transport [108].