Interestingly, SLC38A1 expression is also regulated by MYC in K562 and HeLa cells: Considering that MYC has been shown to be upregulated and that MYC pathway activation cooperates with VHL loss to induce ccRCC [73,74,75], SLC38A1 probably plays an important role in the progression of ccRCC. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.