RNF169 and cancer: We selected Pvt1, a long non-coding (lnc) RNA of which the human ortholog is implicated in cancer progression [23]; Ano3, a member of the Tmem16 family of membrane proteins and a possible potassium channel [24]; Sec14l5, an uncharacterized gene; and, Rnf169, which plays a role in the DDR via interaction with DYRK1A [25].