Although PICT1 may function differentially, as a tumour suppressor or as an oncogene, depending on the environment and conditions, low levels of PICT1 have been found on ccRCC with an inverse correlation to the Fuhrman grade system, which classifies tumours based on nuclear/nucleolar abnormalities [229]. The gene discussed is NOP53; the disease is nonpapillary renal cell carcinoma.