CD4 and infection: Ever since the high-mannose moiety of N-glycans decorating the HIV-1 gp120 protein has been identified as a target recognized by the CD4+ T-lymphocytes in vitro, a step essential to later promote the virion infection of the host cells, man-specific lectins have been deeply investigated as possible agents able to mask the high-mannose target and thus prevent the HIV infection of the host cells by HIV.