IL10 and obesity due to melanocortin 4 receptor deficiency: These extracts showed a reduction of nitric oxide (NO) production, inhibition of the induction of nitric oxide synthase (NOS) and TNF-alpha, and induction of the interleukin 10 (IL-10) gene expression; on this basis, it has been suggested that they could be potential therapeutic tools against the comorbidity associated with the development of obesity [27].