We have previously demonstrated that the overexpression of a dominant-positive, hypoxia-insensitive CREB300/310 mutant enhanced tumor growth, vascularization, and abrogated hypoxia-induced apoptosis, while the dominant-negative form of CREB (KCREB) or knock-down of CREB abolished mouse hepatocellular carcinoma (HCC) tumor growth [8,14]. The gene discussed is CREB1; the disease is neoplasm.