In short, when KYDS occurs, the complex correlation between metabolites and biochemical indicators was broken and reduced, leading to extreme metabolic disorders (i.e., some relations between biochemical indicators and metabolites became absolutely positive correlation (T, ACTH) or negative correlation (T4, 17-OHCS), and some were completely irrelevant (TSH, LH, FSH, and CORT)). The gene discussed is POMC; the disease is Other metabolic disease.