After exclusion of patients with dementia at baseline, and censoring in the main analysis at time of incident dementia diagnosis, effect estimates for mortality remained similar for APOE-ε2 (HR 0.95, 0.90–1.01), but attenuated for APOE-ε4 (HR 1.07, 1.01–1.12) (S1 Table). Here, APOE is linked to dementia.