Different individual CSF cut-off values have been proposed for adults, such as 7.7 pg/mL or 15.4 pg/mL for CXCL13 to predict the progression of CIS to definitive MS [54, 59] and 10 pg/mL for IL-6 to exclude MS [37]. This evidence concerns the gene CXCL13 and myeloid sarcoma.