We observed that the frequency of PD-1-expressing cells was significantly higher in α4β7+ versus α4β7- cells regardless of the HIV infection status (healthy: 19,11% vs. 13,8%, p = 0,0070; viremic: 40,29% vs. 27,48%, p<0,0001) (Fig 3A). The gene discussed is PDCD1; the disease is HIV infectious disease.