In terms of HIV infection, next logical steps will be the determination of the viral reservoir of CD4+ T cells stratified by α4β7 expression in HIV patients treated with VDZ [13,56].We also plan to conduct HIV-specific T cell staining via MHC class I+II tetramers in order to check for possible correlations between integrin-expression and HIV-specific T-cell responses. This evidence concerns the gene CD4 and HIV infectious disease.