Nevertheless, most new identifications are well supported to have tumor promoting effects and therefore warrant further investigation to uncover how DNA-methylation may influence regulation of genes like EHF, FSTL1, PTPRC, S100A9, LTF, EVL, and TSTA3. Importantly, in all these cases the type of DNA methylation is consistent with gene function, where known tumor-suppressors are hyper-methylated and oncogenes are hypo-methylated at regions where DNA methylation negatively regulates transcription. The gene discussed is S100A9; the disease is neoplasm.