As chemokine receptors are pivotal for T-cell migration, we hypothesized that CXCR3 receptor might play an important role in parasite-specific CD8+ T-cells migration into infected tissues after immunization and challenge by T. cruzi. Firstly, we evaluated CCR2 and CXCR3 role during immunization and infection and both CXCR3 and CCR2 receptors are highly expressed in the heart of T. cruzi infected mice [22]. The gene discussed is CXCR3; the disease is infection.