The data in our current study support the notion of a narrowing TCR repertoire in lupus, as we find increased oligoclonality in the TLR7tg CD8+ T cell pool compared with wild type controls: a reduction of the total number of unique clones (Fig. 2), a diversion of CDR3 length away from expected Gaussian distribution (Fig. 3), and skewed VDJβ gene usage (Fig. 4). The gene discussed is CD8A; the disease is systemic lupus erythematosus.