IDH3a was considered to be a target gene of NF‐kB35 and IDH3α‐cSHMT signaling axis represents a novel mechanism of metabolic adaptation in glioblastoma.5 Targeting tumor glycolytic provides new ideas for cancer treatment.36, 37 Tributyltin is an organotin compound that is an endocrine disruptor similar to androgen. The gene discussed is SHMT1; the disease is neoplasm.