The main mechanisms of [18F]‐FDG uptake is involved with increased expression of glucose transporters of cell membrane and rate‐limiting glycolytic enzymes, such as glucose transporters 1 (GLUT1) and hexokinase 2 (HK2).7, 8 AKT is known as "Warburg kinase," which promotes tumor cells metabolic reprogramming and increases cell invasiveness.9 The gene discussed is HK2; the disease is neoplasm.