SHMT1 and cancer: IDH3a was considered to be a target gene of NF‐kB35 and IDH3α‐cSHMT signaling axis represents a novel mechanism of metabolic adaptation in glioblastoma.5 Targeting tumor glycolytic provides new ideas for cancer treatment.36, 37 Tributyltin is an organotin compound that is an endocrine disruptor similar to androgen.