In addition, a growing body of literature demonstrates that CKIP-1 was highly expressed in normal tissues, but extremely lower in some cancer tissues and cancer cell lines, including lung cancer, breast cancer, osteosarcoma, ovary cancer, and colorectal cancer, suggesting the potential tumor suppression ability of CKIP-1 [13, 14]. The gene discussed is PLEKHO1; the disease is osteosarcoma.