PLEKHO1 and central nervous system cancer: Of a total of 87 glioma tissue samples, low expression of CKIP-1 accounted for 21.1% (4 of 19) in the LGG (grades I 3 and II 16) and 88.2% (60 of 68) in the HGG (grades III 27 and IV 41), respectively, and significantly correlated with WHO grade (p = 0.001, Table 1).