PLEKHO1 and central nervous system cancer: These results demonstrated that CKIP-1 arrested glioma cells at the G0/G1 phase which control that cells do not exit from G1 phase and enter into S phase of the cell cycle, while depletion of CKIP-1 reversed the accumulation in the G0/G1 phase and allowed the glioma cells to enter into S phase, suggesting that CKIP-1 may function through its antiproliferative activity in glioma cells.